Hampton Inn Suites Saint Louis South Interstate 55 | Hotel in St. Louis, Missouri

Hampton Inn & Suites - Saint Louis South Interstate 55 is a practical base in Mattese, set directly off Interstate 55 for easy access to the south side of St. Louis. Downtown is 15 miles north, with the Gateway Arch among the city landmarks within reach, while the St. Louis Zoo, Cahokia Mounds State Park, and the Anheuser-Busch Brewery all make for straightforward day trips from the hotel.

Inside, the rooms are set up for an easy stay. Each one includes a flat-screen TV, microwave, refrigerator, and work desk, so you can settle in, store snacks, and keep plans moving between stops. It is an efficient setup for travelers who want the basics close at hand, with the comfort of a room that feels ready for both work and downtime.

The hotel’s shared spaces keep the pace simple. Start the morning with the breakfast buffet, then return later for the indoor pool, spa bath, or fitness center when you want to unwind or reset. There is also a business center, an ATM, and dry cleaning, along with parking, internet, pet friendly accommodations, and accessibility features where needed.

That mix of highway convenience and familiar amenities makes this stay easy to use without feeling disconnected from the city. In Mattese, the location works well for guests who want a straightforward hotel base with quick access to St. Louis and a calm place to return to at the end of the day.