The Frame Hotel | Hotel in Duomo, Florence

The Frame Hotel is a boutique Hotel in Duomo, set in Florence’s historical center and only 820 feet from Florence Cathedral. The location places you close to the city’s most recognizable streets and to Santa Maria Novella Train Station, which is about a 5 minute walk away. Housed in a historical building with original exposed stone and brick, the stay carries a sense of place from the moment you arrive, with a story tied to the recovery of the Mona Lisa in 1913. Inside, each room is individually furnished, so the feel is personal rather than uniform. Expect air conditioning for warmer days, a flat-screen TV for quiet time in, and a private bathroom with toiletries. Some rooms also include a mini-bar, and the property offers wheelchair accessible accommodations where available, along with parking and pet friendly stays, charges may apply. The overall rhythm is straightforward and comfortable, with practical services that support an easy city stay, including transportation and shuttle options, laundry, breakfast, and guest services. After a day in Florence, the exposed masonry and central setting make the return feel calm and rooted in the neighborhood. Step outside and you are in Duomo, where the pace is shaped by daily city life, historic streets, and quick access to the center’s major sights. At The Frame Hotel, the experience feels compact, urban, and distinctly tied to Florence, with the building itself doing much of the storytelling.